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tPA Fact Sheet

IV tPA vs. no treatment

  • Onset to treatment within 3 hours
  • Good outcome with no or minimal deficit 3 months after stroke: 39% vs. 26%
  • Risk of brain bleeding with worsening neurological status 6.4 % vs. 0.6%
  • Risk of Death: 17% vs. 21%
  • Overall, for every 100 patients treated within the first 3 hours, 32 had a better outcome as a result and 3 a worse outcome.
  • Brain hemorrhages related to tPA caused severe worsened final outcome in only 1% of patients.
  • Patients who are treated with IV tPA are discharged home earlier, are more often discharged home versus to a nursing home and report a better quality of life.
  • For every 8 patients treated, 1 has a near normal outcome.
  • For every third patient treated, one has an improved outcome.
Patient with a Stroke that... Had IV tPA treatment No treatment
Good outcome with no or minimal deficit 3 months after stroke 39% 26%
Risk of brain bleeding with worsening neurological status 6.4% 0.6%
Risk of Death 17% 21%